Commensal gut bacteria and the etiopathogenesis of rheumatoid arthritis.
نویسنده
چکیده
3. Information on permissions/orders of reprints in rheumatology and related fields. Silverman featuring research articles on clinical subjects from scientists working is a monthly international serial edited by Earl D.
منابع مشابه
Loss of Sex and Age Driven Differences in the Gut Microbiome Characterize Arthritis-Susceptible *0401 Mice but Not Arthritis-Resistant *0402 Mice
BACKGROUND HLA-DRB1 0401 is associated with susceptibility, while HLA-DRB1 0402 is associated with resistance to developing rheumatoid arthritis (RA) and collagen-induced arthritis in humans and transgenic mice respectively. The influence of gut-joint axis has been suggested in RA, though not yet proven. METHODOLOGY/PRINCIPAL FINDINGS We have used HLA transgenic mice carrying arthritis suscep...
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Commensal microbes can have a substantial impact on autoimmune disorders, but the underlying molecular and cellular mechanisms remain largely unexplored. We report that autoimmune arthritis was strongly attenuated in the K/BxN mouse model under germ-free (GF) conditions, accompanied by reductions in serum autoantibody titers, splenic autoantibody-secreting cells, germinal centers, and the splen...
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Rheumatoid arthritis (RA) is a multifactorial disease and requires interaction between genetic and environmental factors for predisposition. The presence of bacterial DNA of the gut residing commensals in synovium as well as dysbiosis of certain commensal bacteria in faecal samples of RA patients as compared to controls suggest a significant role of the gut flora in pathogenesis of RA. The gut ...
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Background and purpose: Recent studies suggest that the viable but nonculturable (VBNC) bacteria could cause inflammatory diseases. The aim of this study was to detect and investigate the expression of nuc and rfbE genes in blood samples of patients with rheumatoid arthritis (RA). Materials and methods: In this experimental study, 102 blood samples were collected from patients with RA and univ...
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عنوان ژورنال:
- The Journal of rheumatology
دوره 35 8 شماره
صفحات -
تاریخ انتشار 2008